Come off GLP-1s without regaining the weight
A physician-planned taper, a dietitian and trainer to protect your muscle, and a HYROX race to train for. Led by obesity medicine physician Dr. Angela Tran, DO.
Three ways in
Start a GLP-1 the right way
Labs and a medical evaluation first. If medication is right for you, Dr. Tran starts low, adjusts at every check-in, and pairs it with a plan for eating and training.
Text us about starting →Come off without starting over
Already on one, from us or from an app? We plan the taper, protect your muscle, and coach you weekly through the months when regain usually happens.
Text us about coming off →Train for your first HYROX
A race date gives the weight loss a finish line, and the training builds the muscle that keeps it off. Scaled from wherever your fitness is today.
Text us about HYROX →
Dr. Angela Tran, DO
Dr. Tran opened Med-Fit in 2012 after years as an internist watching what excess weight does to the body. She built the practice she wanted for her own patients: a doctor, a dietitian, a health coach and a trainer working from one plan.
She prescribes GLP-1s every week, and she'll tell you the same thing she tells every patient: you can get healthy with or without medication. The medication is a tool. The habits are what you keep.
In a major trial, people who stopped semaglutide regained about two-thirds of the weight they'd lost within a year.
STEP 1 trial extension, Wilding et al., Diabetes, Obesity and Metabolism, 2022
In a smaller study, patients who tapered off semaglutide over about nine weeks, with diet and exercise coaching, kept a stable weight for the next six months.
Embla clinic data, European Congress on Obesity, 2024 · small observational study
The GLP-1 ends. The plan shouldn't.
Most regain happens in the first months after the last dose, when appetite comes back and muscle lost along the way slows your metabolism. That's the part we plan for.
Give the weight loss a finish line
HYROX is eight 1 km runs, each followed by a workout station. It's built for ordinary people, it rewards consistency over talent, and a race date is a better reason to keep training than a number on a scale. Denver hosts its first HYROX this November.
What it costs
We don't bill insurance. Most patients pay with an FSA or HSA card. Medication memberships need a 3- or 6-month commitment. Visits, check-ins and coaching can all be done online.
For people who already have their eating and training in place and need the medical piece.
Everything in RX Plus for six months, long enough to reach a dose that works and plan what comes after.
Dr. Tran plus a registered dietitian, health coach and certified trainer, meeting with you every week.
One plan, four people behind it
Look under the hood
Labs for insulin resistance, thyroid and more, plus your full history and an honest look at your week.
Your plan, in writing
Dr. Tran decides whether medication belongs in it. Your dietitian and trainer turn it into meals and workouts that fit.
Every week, someone checks in
Alternating sessions with your coach and dietitian, and secure chat with the team between visits.
A plan for after
Maintenance, a taper if you're on medication, and a goal to train for so the habits outlast the program.
“Not a one size fits all”
Shared by our patients. Individual results vary.
“As a medical provider… I have referred my patients to this program because I know it is a formula for success!”
“Dr. Tran did a full blood work up and assessment and to my surprise I was not eating enough.”
“A very helpful team that will accommodate to your schedule to help you reach your goals, and maintain balance after you reach them.”
Sample review: I was scared to stop my GLP-1. Dr. Tran tapered me slowly and my coach kept me on track the whole way.
Sample · GoogleSample review: I signed up for my first HYROX as my goal after the program. I never thought I'd be the person pushing a sled.
Sample · GoogleSample review: Doing it all online made it possible with my schedule. Someone checked in every single week.
Sample · GoogleProgress you can see
Sample photos. Your consented patient photos replace these. Individual results vary.
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In Castle Rock, or online
See us in person in Castle Rock, or do your consultation and check-ins online from anywhere in Colorado. Patients come to us from Denver, Lakewood, Aurora, Westminster and Wheat Ridge, and online from Colorado, Arizona, Michigan, Illinois and Texas.
Fri 8am–11:30am
Coming off GLP-1s: questions people ask
What happens when you stop taking a GLP-1?
Appetite and cravings usually return within weeks, and in trials most people regained a large share of the weight within a year of stopping. Blood sugar can also rise, especially with diabetes or prediabetes. At Med-Fit, stopping is planned with your physician and coached week by week.
Can you stop semaglutide cold turkey?
It is possible, but most experts don’t recommend it, because appetite can return quickly and blood sugar can swing. A gradual taper with your prescriber is the usual approach. Dr. Tran plans tapers for patients whether they started with us or elsewhere.
How do you taper off a GLP-1?
Tapering usually means lowering the dose or spacing injections further apart, for example every 10 to 14 days instead of weekly, over several weeks or months. Protein, strength training and eating structure are built up at the same time. The right pace depends on your dose, history and labs, so your prescriber should set it.
Is there withdrawal when you stop a GLP-1?
GLP-1 medications don’t cause true withdrawal or dependence. What people notice is the medication’s effects wearing off: more hunger, more food noise and faster digestion. Semaglutide takes about five weeks to fully leave the body, so these changes build gradually.
How do you keep muscle while losing weight on a GLP-1?
Eat enough protein at every meal and do strength training at least two to three times a week. Without both, a meaningful part of the weight lost can be muscle, which makes regain more likely. Every Med-Fit plan includes protein targets and a training plan.
How much protein should you eat on a GLP-1?
Many obesity medicine guidelines suggest roughly 1.0 to 1.5 grams per kilogram of ideal body weight per day, spread across meals. Smaller appetites make that hard, so planning matters more than willpower. Your dietitian sets a target that fits your labs and your week.
What are the most common GLP-1 side effects?
Nausea, reflux, diarrhea, constipation and an upset stomach are the most common, especially when the dose goes up. Starting low and increasing slowly usually helps. Dr. Tran adjusts your dose at every check-in.
Is HYROX good for weight loss?
HYROX training combines running with strength work like sled pushes, lunges and wall balls, which builds muscle while burning energy. It is scalable for beginners, and a race date gives you a reason to keep training once the weight is off. Our trainers scale HYROX programming to where your fitness is today.
